Comment · Mon, January 25, 2016 · Ceretropic & Nootropics Depot
Four(-ish) questions about NA-Selank!
Original post in this thread
srubek · 10 points
ONE
It is widely accepted that NA-Selank's calming properties are attributable to its "induction of the metabolism of serotonin," right?
So my first real question is, what does that mean? Does it induce metabolism of serotonin into serotonin metabolites; or does it metabolize potential precursors into serotonin itself?
If the answer is the latter, then does this result in a net increase in serotonergic synaptic activity, or just an increase in synthesis & storage of it in the presynaptic vesicles?
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TWO
I'm also curious by what all mechanisms this is considered a nootropic...
So secondly, is its release of BDNF/NGF exclusive to the hippocampus?
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THREE
I've noticed that NA-Semax Amidate has an anxiolytic component to it; an effect that its non-amidated version is missing...and I would like to have that anxiolysis at night but without Semax's stimulation...hence my third big question:
Would it potentially be more effective, anxiolytic, and/or longer lasting with an 'amidated' C-terminus or other...terminus? (please forgive and correct my technical errors--I prefer precision, and…
What they were answering
cuppercakez · 1 points
What's this about copper? "Have they confirmed that amidating the molecule changes how it binds to copper?"—they?—they who?
Links to science news/research articles from which y'all are reading, please :)
In a nutshell, what is the relevance/importance of copper binding in consideration of Selank (and Semax)?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
It does not affect Selank, only Semax. So essentially Semax acts as an antioxidant, and chelates reactive copper II from cells, where it can be causing damage. Once complexed, it is very stable. So Semax can be pulling excess oxidative copper II from cells, and regulating their levels.