Anyone else interested in P21 nasal spray from Ceretropic?

Comment · Thu, August 20, 2015 · 25 pts

Trust me, I know. I've gotten hundreds, if not thousands, of emails about it. Our labs are not cooperating. The original lab will not do it anymore, due to the difficulty of synthesis. One of the new labs wants way too m

Comment · Thu, August 20, 2015 · 5 pts

We are planning on having at least a small scale solid phase peptide synthesis lab at some point. The two things holding us back are: not having someone skilled in solid phase peptide synthesis to run it, and the initial

Comment · Thu, August 20, 2015 · 5 pts

Apparently the adamantine moiety can cause explosions during the synthesis! That's two different synths now that we have caused unexpected explosions at labs. Haha

Comment · Thu, August 20, 2015 · 5 pts

You are looking at the wrong P21. There are two compounds commonly referred to as P21.

Comment · Thu, August 20, 2015 · 6 pts

How do they alter the biosynthesis to achieve the specific sequences? Would it only be able to be used for standard amino acid sequences?

Comment · Fri, August 21, 2015 · 3 pts

Those synths are a lot more common, so they have been perfected. The amino acid used in P21 is a very uncommon one. So labs are not as familiar with efficiently producing it.

Comment · Fri, August 21, 2015 · 3 pts

We have both N-Acetyl Epitalon and N-Acetyl Epitalon Amidate on the way to us as we speak. It will be cheaper than TLR. I have not tried either of them yet, though.

Comment · Fri, August 21, 2015 · 4 pts

That's seems very interesting! I'll have to look into it a bit. Is Lucigen the people to speak to about it?

Comment · Fri, August 21, 2015 · 2 pts

We just started that with Semax. We will probably do it with Selank (We have NA-Selank Amidate on the way too). I can see what we can do with Epitalon. We would have to get smaller vials for it, but that is doable.

Comment · Fri, August 21, 2015 · 2 pts

Yeah, I have been reading up on Thymalin. I have not approached my lab about it yet, though.

Comment · Fri, August 21, 2015 · 3 pts

Haha, I did think about creating a name for it when we first brought it out. I decided against it when people got upset at me for naming Hydrafinil. Plus, it is not my peptide. It was developed by the New York State Inst

Comment · Fri, August 21, 2015 · 1 pts

It's going to protect the C-terminus, like it does in Semax. I have not tried it yet, so I cannot say how it is going to affect the subjective effects. It should make the peptide less charged, and make it easier to pass

Comment · Fri, August 21, 2015 · 2 pts

Ohh, ok. So Lucigen is just selling the e coli strain to be used in the process. I am going to have to do a lot more reading on it. I'm sure it would take some work to get it to a point that it would be cost effective fo

Comment · Fri, August 21, 2015 · 2 pts

Now that is a good one! I've got other compounds I am working on that I am going to name. I am not using the number designation from studies anymore.

Comment · Fri, August 21, 2015 · 1 pts

So longer sequences would be able to be done a lot cheaper per unit, once the initial setup cost was done. It could be a very cool project to try down the line.

Comment · Fri, August 21, 2015 · 2 pts

Haha, you have no idea. I can't even begin to describe how crazy my life has gotten. It has been fun, though!

Comment · Fri, August 21, 2015 · 2 pts

Don't get me wrong, there are quality Chinese suppliers. Our liquid piston filler and new automated labeling machine were made by a good manufacturer in China. It's just for every 1 quality company, there are 10 shitty o

Comment · Sat, August 22, 2015 · 1 pts

That explosion is actually causing a ton of issues. All outbound packages from China are going through two more inspections now. One Chinese government inspection, and another private carrier inspection.

Comment · Sat, August 22, 2015 · 6 pts

Ohh man, we have a lot of secrets ahead!