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Comment · Wed, August 5, 2015 · Ceretropic

Has anyone attempted to extract bacopaside XII or synthesize it?

Original post in this thread

srubek · 14 points

Edit: changed bacopaside XII to bacopaside XI - my mistake

Excuse my naivete when it comes to reddit rules...I hope I don't mess something up. Please correct me if I'm wrong. Still learning.

Everyone seems to really like bacopa in the nootropic subreddit community...but all the extracts and powders that I can find seem to be standardized for bacosides, not bacopasides. And when I look at the wiki for brahmi, the only chemical reference that I can directly relate to its nootropic benefit seems to be bacopaside XI.

Again, please correct me if I'm wrong.

And I'm not suggesting that anyone should isolate and consume bacopaside XI in large amounts or anything, but I'm interested if anyone has tried to synthesize the molecule or knows of anyone who has. Or if that even makes sense...

Again, excuse my naivete.

I did find this, which I feel like...is maybe a step in the right direction:
http://www.nrcresearchpress.com/doi/abs/10.1139/v09-111?mobileUi=0&#.VcEWLJNViko

But alas, not much more.

I'm very intrigued by this Bacopaside, and by the mechanism & chemical constituents behind its nootropic & mood enhancing properties. Enlighten me, reddit?

What they were answering

Debonaire_Death · 3 points

It might be better to find a specialized means of cultivation to maximize the bacopa's natural production of bacopasides, unless this has already been done. I know that something similar was done with Lion's Mane in at least one study, using garlic extract to produce mushrooms with a subsequent extract capable of almost performing as well as pure NGF in a rat model.

Or has this already been pursued with bacopa? I'm not sure how new of a concept it is giving plants drugs to make them stronger.

It might also be good to see what chemicals potentiate bacopasides, so that they could be paired together in amounts that are commercially viable, although based on the current yields this wouldn't currently be such.

u/MisterYouAreSoDumb · Ceretropic

It certainly might be an option at some point. I think optimizing the cultivation of the plant, and extraction of the compound, is going to be a more doable plan than straight synthesis.

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