Will 23andme offer any insight into improving my cognition?

Comment · Sat, July 18, 2015 · 5 pts

Let me guess, you have mutations on MAO-A and COMT, but also have a couple MTHFR or MTRR mutations as well?

Comment · Sun, July 19, 2015 · 9 pts

That is why there is conflicting results. Those sites are a good place to start your searching. However, they cannot program everything into the algorithm that suggests things. When you have MAO-A and COMT mutations, yo

Comment · Mon, July 20, 2015 · 1 pts

Lithium can help regulate COMT. It takes a while to work, though. MAO-A expression is kind of hard to change. Oxidative stress up-regulates MAO-A. However, you don't really want to do that! The best approach is to try an

Comment · Mon, July 20, 2015 · 1 pts

There is no single place, unfortunately. It takes a lot of reading, and a lot of experimenting. Even my suggestions are just a starting point.

Comment · Mon, July 20, 2015 · 1 pts

Try taking TMG in isolation, and then seeing how you feel. You can try SAMe. However, start with low dosages.

Comment · Mon, July 20, 2015 · 2 pts

I answer probably 5 people a week about this stuff. If you send your results over, I can look at them when I have some time. Sometimes that can take a few days, though. It just depends on how busy I am.

Comment · Tue, July 21, 2015 · 1 pts

Hmm, that should be legit. It is curious as to why you reacted so poorly to methyl-b12, but not to methylfolate. They both should increase serotonin production.

Comment · Tue, July 21, 2015 · 1 pts

Dietary sulfur comes from methionine, cysteine, and taurine; usually in the form of proteins. The methylation cycle regulates the production of compounds in the body that require sulfur. One of the most common sulfur con

Comment · Tue, July 21, 2015 · 2 pts

Yeah, when you have mutations that conflict, those site recommendations fall pretty flat. It would be better if they just stuck to explaining the mechanisms. But then people want more explanation. It's just a complex thi