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Comment · Wed, June 17, 2015 · Ceretropic

Ceretropic's EPITALON

Original post in this thread

stackonstackonstack · 30 points

just got an e-mail. don't know much about it right now. Wanted to hear what the peanut gallery's got especially studies...

What they were answering

GetOutOfBox · 12 points

The problem with telomerase activation is that we need to find some way to profoundly reduce ordinary DNA damage; telomeres act as a self-destruct mechanism to guarantee the cell's eventual destruction (as all cells will eventually suffer enough damage that they cease to function properly with the body). Bypassing this mechanism simply lays the groundwork for cancerous cells to take hold of the body.

So while activating telomerase like Epitalon may extend life and reduce the effects of aging, it likely significantly increases the risk of developing cancer.

u/MisterYouAreSoDumb · Ceretropic

Good thing it has been shown to inhibit carcinogenesis too!

Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER‐2/neu transgenic mice

Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats

Effect of the Synthetic Pineal Peptide Epitalon on Spontaneous Carcinogenesis in Female C3H/He Mice

The mechanisms of Epitalon are a lot more complex than just activating telomerase. It reduces lipid oxidation and ROS, along with normalizing T cell function. It seems to normalize cholesterol and uric acid, along with prolactin levels. So the increased length of telomeres is just a single part of it. Epitalon seems to be a very promising peptide.

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