Phenylethylidenehydrazine Update?

Comment · Mon, April 13, 2015 · 7 pts

I was. However, the production synthesis failed to scale up from the test batches. I will be revisiting it soon.

Comment · Tue, April 14, 2015 · 3 pts

Just regular phenylethylamine?

Comment · Wed, April 15, 2015 · 3 pts

Yeah, phenylethylamine is the basis for a lot of stimulant drugs out there. Increasing dopamine release can increase oxidative stress, which can lead to Parkinson's symptoms.

Comment · Wed, April 15, 2015 · 2 pts

Amphetamine is modified phenylethylamine. Alexander Shulgin made tons of modifications to phenylethylamine. It's one of the most modified substances out there.

Comment · Wed, April 15, 2015 · 2 pts

Amphetamine is very close to phenylethylamine. Any modifications to prevent the breakdown of it by MAOI are going to make that compound a structural analog to a schedule 2 substance, which the DEA does not take too kindl

Comment · Wed, April 15, 2015 · 1 pts

Everything is going to have certain tradeoffs. The more dopaminergic the substance is, the more effective it will be. However, it will also build tolerance faster, and have a higher risk of addiction. Acting directly on

Comment · Wed, April 15, 2015 · 2 pts

Sure, you can do that. A lot of people are using Memantine to keep tolerance at bay. There are even NMDA antagonists found naturally in kratom, which is why it does not build tolerance as fast as other opioids.

Comment · Thu, April 16, 2015 · 2 pts

No, because most of the brain fog from Memantine is from the nicotinic ACh antagonism, not the NMDA antagonism.

Comment · Thu, April 16, 2015 · 2 pts

Yes, I would say it is safe long-term.