Comment · Sat, April 4, 2015 · Ceretropic
Sublingual Noopept... Wow
Original post in this thread
HalfBakedIndividual · 28 points
10mg sublingual is more powerful than 40mg orally, it feels stimulating and my brain is ridiculously clear. You need to try this, I had pills and just chewed it and kept it in my mouth for 10 minutes.
What they were answering
coder_for_hire · 1 points
I've always wondered about the specific bioavailability. How did we arrive at 9%?
u/MisterYouAreSoDumb · Ceretropic
The absolute bioaccessibility was on the average AUC p.o./ AUC i.v. = 9.33 +-1.30%, which is evidence of a pronounced effect of the “first passage” via the gastrointestinal tract and the liver. In comparison with rats, rabbits are characterized by slower absorption of the parent substance, which is manifested by an almost twofold increase in MRT and by decrease in the C max AUC 0 ratio in the latter case.
That is going to vary a bit in humans, though.