Comment · Sat, April 4, 2015 · Ceretropic
Is tianeptine NMDA agnostic or antagnostic?
Original post in this thread
vdog26 · 5 points
Been reading up on research as much as I can without hitting a pay wall, wondering if anyone who has done a good
What they were answering
zensunset · 1 points
I would love some deeper explanation on this. Any directions you could point me towards?
I'm taking both concurrently.
u/MisterYouAreSoDumb · Ceretropic
So Tianeptine is modulating the current between the AMPA and NMDA receptors, right? The NMDA receptors are what opens to allow calcium into the neuron, and create an electrical potential, which allows signals to propagate across neurons. For the NMDA receptors to be able to open, the AMPA receptors have to activate, and depolarize the neuron. That allows the magnesium blockage in the NMDA channel to get out of the way, and allow calcium in. With Tianeptine modulating the current between the AMPA activation and NMDA depolarization, that is going to affect how Memantine binds. That is because Memantine binds to an open channel binding site on the NMDAR. So the magnesium blockage has to clear for that to happen. Since Tianeptine is altering the current from the AMPA receptors, the depolarization of the cell is going to be different.
I was postulating that since Tianeptine normalized those currents, that it would actually help Memantine's actions. They would both be working to prevent too much calcium from entering the cell from over-excitability/stress.