Comment · Fri, October 24, 2014 · Ceretropic
New Tianeptine Studies
Original post in this thread
al0ne_together · 11 points
I am interested to hear your opinions about the new studies showing that tianeptine is a full agonist at the mu and delta opioid receptors
My reaction was somewhat mixed when I read about it. As someone who takes tianeptine for depression, I am very interested in the studies about it. I began using as an adjunct to an ssri, and I can say it gives me a really nice mood lift and helps me focus and relax. However I saw many people on drug forums discussing abusing it and comparing it to oxycodone, which bothered me somewhat because naturally most people would be weary of taking opioids
My questions are how does it change your view of the drug? For those of you who have taken other opiates, what is it comporable to in terms of mental and physical effects? And if it is very comparable to say, oxycodone or tramadol, how is its M.O.A different? Many of its effects have been known for years, such as the dopamine release and production of BDNF, most of which actually fit the mechanisms of opiates. So is Tianeptine just an opiate or are there other mechanisms too? I am very interested to hear other people's thoughts about this.
What they were answering
al0ne_together · 1 points
Thanks for the link. I'll be interested to see if new studies can pinpoint exactly what causes the changes in glutamate signaling. I thought maybe it had to do with the opiate action but it seems like that's probably not the case. I find it interesting that this drug was put on the market as an antidepressant without knowing the mechanism of action and 30 years later we're still finding out new things about it.
u/MisterYouAreSoDumb · Ceretropic
That's how things usually work. The drug companies care more about efficacy than mechanisms. It's eye opening to think about.