Comment · Fri, October 24, 2014 · Ceretropic
New Tianeptine Studies
Original post in this thread
al0ne_together · 11 points
I am interested to hear your opinions about the new studies showing that tianeptine is a full agonist at the mu and delta opioid receptors
My reaction was somewhat mixed when I read about it. As someone who takes tianeptine for depression, I am very interested in the studies about it. I began using as an adjunct to an ssri, and I can say it gives me a really nice mood lift and helps me focus and relax. However I saw many people on drug forums discussing abusing it and comparing it to oxycodone, which bothered me somewhat because naturally most people would be weary of taking opioids
My questions are how does it change your view of the drug? For those of you who have taken other opiates, what is it comporable to in terms of mental and physical effects? And if it is very comparable to say, oxycodone or tramadol, how is its M.O.A different? Many of its effects have been known for years, such as the dopamine release and production of BDNF, most of which actually fit the mechanisms of opiates. So is Tianeptine just an opiate or are there other mechanisms too? I am very interested to hear other people's thoughts about this.
What they were answering
al0ne_together · 1 points
Yeah I remember this from Longecity, thanks for posting this!
My question is where do Tianeptine's effects on neuroplasticity come from? The study showed that tianeptine only directly activates the opioid receptors, yet it has all these effects on dopamine levels and nmda receptor activity.
u/MisterYouAreSoDumb · Ceretropic
It normalizes the current between the different types of glutamate receptors. This prevents excitotoxicity from stress. The increase in BDNF is largely the mechanism behind the neuroplasticity effects. But the glutamate modulation is playing a large role as well.
https://mega.co.nz/#F!RUAAjJQZ!S5sxyV4XZxvqF67Fo3Gctw
There are a lot of full studies on it. Have a read through a few of them, and you will see how complex the mechanism is.