Comment · Sun, August 24, 2014 · Ceretropic
Tianeptine PSA on Longecity – Any Legitimacy?
What they were answering
killword-noot · 1 points
Interestingly, 7-HM (*actually, I think mitragynine has the most delta activity) and tianeptine also have delta opioid affinity where activation does indeed show neurogenic ability but the affinity for that receptor with tianeptine is even lower than that for MOR.
u/MisterYouAreSoDumb · Ceretropic
Yeah, I am not sure if that is playing a huge role. It might be a minor one. But the glutamate modulation and BDNF seem to be the main neurogenetive mechanism with tianeptine.
I do think kratom needs some more research. I would love to see some studies on the various levels of alkaloids, and the effects they cause; similar to how marijuana has seen an explosion in research. High CBD marijuana strains are showing great effects with a lot of diseases. I think there is a lot of untapped potential in kratom as well.