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Comment · Fri, July 25, 2014 · Ceretropic

SEMAX as an antidepressant?

Original post in this thread

dilated_student · 6 points

Since both SEMAX and ketamine have been shown to increase BDNF singificantly after adminstration.[1][2]
Furthermore, BDNF increase is suggested as a biomarker relevant to antidepressant response for ketamine[2] and other more common antidepressants.[3]

[1]. http://www.ncbi.nlm.nih.gov/pubmed/16996037
[2]. http://www.ncbi.nlm.nih.gov/pubmed/24103211
[3]. http://www.ncbi.nlm.nih.gov/pubmed/21749907

Soo, did anyone notice any kind of effects on depression/low mood from SEMAX?

NOTE: I don't have any experience with SEMAX.

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic

It certainly gives me an uplifting feeling. It is like the feeling after a good workout. Just a nice natural stimulated feeling with some elevated mood. Combining it with tianeptine works even better.

That being said, depression is a very complicated thing. Not everyone is going to experience it in the same way. I do think those suffering from certain types of lethargic depression could benefit from it. However, one's doctor should be consulted before trying to use it as a treatment.

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