Comment · Tue, February 11, 2014
MDA with a SSRI
Original post in this thread
wolpertinger777 · 12 points
I'm a huge fan of MDA for its psychedelic properties. It has a really special "outrospection" that I have yet to experience in other substances.
The only problem for me is its supposed neurotoxicity because of monoamine release. Would using an SSRI (such as kanna) remove the serotonin releasing properties of the drug and therefore curb the issue of neurotoxicity?
I know that the compound might feel a little different without the serotonin release and the psychedelia might require higher dosages but would it still be effective?
TO SUM UP: Would using an SSRI (such as kanna) with MDA block the serotonin releasing properties and thereby create a non-neurotoxic dopamine/norepinephrine releasing agent with 5ht2a agonism?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
MDMA actually causes a release of serotonin by binding to pre-synaptic 5-HT2B receptors. This signals the transporter to reverse. If you are blocking the transporter, that reversal is going to be interrupted, leading to less of the effects people want in an MDMA roll. However, taking an SSRI at the end of the roll has been shown to prevent 5-HT system damage. That is because it block the reactive oxygen species from being uptaked into the neuron to cause damage. There is a big caveat, though. The SSRI cannot be taken past the 6hr mark of the roll, or it will not prevent the damage. The SSRI they used for those studies was fluoxetine. However, the mesembrine from the kanna should work as well.
EDIT: I just realized that I typed MDMA instead of MDA. Irregardless, the mechanism is the same for both. The same goes for something like 6-APB.