Comment · Wed, February 12, 2014
MDA with a SSRI
Original post in this thread
wolpertinger777 · 12 points
I'm a huge fan of MDA for its psychedelic properties. It has a really special "outrospection" that I have yet to experience in other substances.
The only problem for me is its supposed neurotoxicity because of monoamine release. Would using an SSRI (such as kanna) remove the serotonin releasing properties of the drug and therefore curb the issue of neurotoxicity?
I know that the compound might feel a little different without the serotonin release and the psychedelia might require higher dosages but would it still be effective?
TO SUM UP: Would using an SSRI (such as kanna) with MDA block the serotonin releasing properties and thereby create a non-neurotoxic dopamine/norepinephrine releasing agent with 5ht2a agonism?
What they were answering
Herperderperton · 1 points
Would you expect DMT to cause serotonin release then? Its a 5-ht2b agonist as well as a 5-ht2a agonist. Also, it pretty much means that you can't have a non-cardiotoxic empathogen.
u/MisterYouAreSoDumb
Indeed, DMT does cause a release of serotonin.
https://mega.co.nz/#!VJoGVKKD!Ee6NFR5EwQqWMta0h1i5gKfbzwXlRl0I4TVyilWVp_Q
In agreement with previous results, we foudn that LSD and N,N-dimethyltryptamine produce a significant (P<0.05) increase in the serotonin in the rat brain and a decrease in the 5-HIAA.
Also yes, it seems that the 5-HT2B receptor is necessary for the main action of most empathogens, so there will always be a risk of cardiotoxicity.