Comment · Thu, February 13, 2014
MDA with a SSRI
Original post in this thread
wolpertinger777 · 12 points
I'm a huge fan of MDA for its psychedelic properties. It has a really special "outrospection" that I have yet to experience in other substances.
The only problem for me is its supposed neurotoxicity because of monoamine release. Would using an SSRI (such as kanna) remove the serotonin releasing properties of the drug and therefore curb the issue of neurotoxicity?
I know that the compound might feel a little different without the serotonin release and the psychedelia might require higher dosages but would it still be effective?
TO SUM UP: Would using an SSRI (such as kanna) with MDA block the serotonin releasing properties and thereby create a non-neurotoxic dopamine/norepinephrine releasing agent with 5ht2a agonism?
What they were answering
Herperderperton · 1 points
d-methamphetamine causes relatively more serotonin release than dextroamphetamine, but I've never heard any reference to 5-ht2b agonism for methamphetamine. Also, MDMA, like classic amphetamines, still causes dopamine and norepinephrine release, presumably by a VMAT mediated mechanism, even if serotonin release is via a different pathway. I remember some more selective serotonin releasing agents like MBDB were reported to lack the energy and euphoria of MDMA because of the lack of norepinephrine and dopamine release.
The releasing agent table on the wiki page seems to have been compiled fairly well and shows the comparative efficacy of release of serotonin, norepinephrine and dopamine of a range of stimulants, including MDMA and MDA.
u/MisterYouAreSoDumb
I believe MDMA induces a release of dopamine and norepinephrine by binding to the 5-HT2A and 5-HT2C receptors. This is most likely compounded by the increase in extracellular 5-HT, as that would bind to all subtypes non-selectively.
MDMA's effects are reliant on a functioning SERT and DAT, but do not act directly on them. It seems its actions are more modulatory from pre-synaptic 5-HT subreceptors.