MDA with a SSRI

Comment · Tue, February 11, 2014 · 15 pts

MDMA actually causes a release of serotonin by binding to pre-synaptic 5-HT2B receptors. This signals the transporter to reverse. If you are blocking the transporter, that reversal is going to be interrupted, leading to

Comment · Tue, February 11, 2014 · 1 pts

Yes, MDMA is different than something like amphetamine. MDMA only leads to small non-significant changes VMAT-2 expression in the neuron itself. When I first got into it, I figured the mechanisms were similar, just for 5

Comment · Wed, February 12, 2014 · 1 pts

Indeed, DMT does cause a release of serotonin. https://mega.co.nz/#!VJoGVKKD!Ee6NFR5EwQqWMta0h1i5gKfbzwXlRl0I4TVyilWVp_Q >In agreement with previous results, we foudn that LSD and N,N-dimethyltryptamine produce a signi

Comment · Wed, February 12, 2014 · 1 pts

I would assume that is due to the much smaller active dosages with DMT and LSD. However, there could be another mechanism at play that we don't know about.

Comment · Thu, February 13, 2014 · 1 pts

I believe MDMA induces a release of dopamine and norepinephrine by binding to the 5-HT2A and 5-HT2C receptors. This is most likely compounded by the increase in extracellular 5-HT, as that would bind to all subtypes non-

Comment · Thu, February 13, 2014 · 1 pts

Right, it seems that it has to be a multi-receptor mechanism. Simply antagonizing the 5-HT2C receptor is not enough. That is why I thought the 5-HT2A activation, paired with the 5-HT2C inactivation, could be the key. >I

Comment · Thu, February 13, 2014 · 1 pts

I would agree. It has to be a combined mechanism. I'll have to do some more digging. I had a good study showing the higher 5-HT release from 6-APB, but I cannot seem to find it right now. I'll try to tomorrow after I get

Comment · Thu, February 13, 2014 · 2 pts

Because it seems to up-regulate the SERT as well, which normalizes the extracellular levels quicker. http://www.ncbi.nlm.nih.gov/pubmed/7892432