Comment · Tue, February 11, 2014
MDA with a SSRI
Original post in this thread
wolpertinger777 · 12 points
I'm a huge fan of MDA for its psychedelic properties. It has a really special "outrospection" that I have yet to experience in other substances.
The only problem for me is its supposed neurotoxicity because of monoamine release. Would using an SSRI (such as kanna) remove the serotonin releasing properties of the drug and therefore curb the issue of neurotoxicity?
I know that the compound might feel a little different without the serotonin release and the psychedelia might require higher dosages but would it still be effective?
TO SUM UP: Would using an SSRI (such as kanna) with MDA block the serotonin releasing properties and thereby create a non-neurotoxic dopamine/norepinephrine releasing agent with 5ht2a agonism?
What they were answering
Borax · 3 points
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Consistently great contributions, and I did not know that. MDMA is different, affecting VMAT in the synapse, yes?
u/MisterYouAreSoDumb
Yes, MDMA is different than something like amphetamine. MDMA only leads to small non-significant changes VMAT-2 expression in the neuron itself. When I first got into it, I figured the mechanisms were similar, just for 5-HT instead of DA. However, they act very differently.
The implications of this are many. For one, you don't have the long-lasting VMAT-2 remodeling that you see in amphetamine. And two, you have vasoconstriction implications. This is why 6-APB releases more serotonin than MDMA. It has a higher affinity for 5-HT2B receptors, consequently leading to more vasoconstriction.