Skip to content

Comment · Mon, November 4, 2013 · Ceretropic

Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers

What they were answering

judasblue · 3 points

Well, I am not sure that this study is the end all on this mood thing.

There are other studies showing that moda helps with at least some elements of depression.

http://www.ncbi.nlm.nih.gov/pubmed/10847314

http://www.ncbi.nlm.nih.gov/pubmed/10847314

http://www.josephmatta.com/modafinil.pdf

Of course, all of that only relates to people who are somehow broke to start with.

u/MisterYouAreSoDumb · Ceretropic

Well modafinil increases extracellular dopamine in the same way methylphenidate does, by inhibiting the DAT. So there will be some mood elevation because of that. It will mask some of the symptoms, but not really lead to long-term progress. Also, there will be some low-level DA receptor down-regulation in response to that increase. So it may be counterproductive in the long run.

http://www.jneurosci.org/content/29/9/2663.full.pdf

>a recent positron
emission tomography study in monkeys
indicated 50% binding of modafinil to the
DAT at lower plasma concentrations than
are induced by therapeutic doses (Madras
et al., 2006). Moreover, mice lacking the
DAT do not exhibit modafinil-induced
wakefulness

http://jpet.aspetjournals.org/content/319/2/561.full

For comparative purposes, a parallel study was conducted with methylphenidate, again at a clinically relevant dose (0.3 mg/kg). Methylphenidate occupied comparable levels of DAT at a dose of 0.3 mg/kg (Table 1).

So it took .3mg/kg to inhibit the DAT to the same degree as 8mg/kg of modafinil. So it's not as powerful as methylphenidate weight for weight, but can be at the right dosage.

http://www.sciencedirect.com/science/article/pii/S0376871602003356

That study showed that modafinil actually decreased euphoria from cocaine when administered concurrently.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696807/

That study showed that modafinil decreased cocaine's binding potential, so it makes sense.

Other MYASD lines in this thread

Related in the archive

Commentr/NootropicsSep 20, 2013

Modafinil Dosing

Replying to Brukhar1 · It's only approved in the USA for narcolepsy and (sometimes) sleep apnea. Narcolepsy is pretty rare so it's not surprising most pharmacists don't know much about it. I remember r

Yeah, but I hold pharmacists to a higher standard. Their whole job is to have at least a basic understanding of all the drugs they provide. When I can go in there and teach the pharmacist about many of the substances, th

10ModafinilDosing
Commentr/NootropicsOct 9, 2013

Adrafinil Experience - Effects & Review

Replying to MisterYouAreSoDumb · Adrafinil is **NOT** toxic to the liver. That is a myth being propagated over the internet without citation. Please don't spread it. It does raise liver enzymes over time. Many dr

Here are sources and reasonings for my assertion that adrafinil is NOT toxic to human livers. As if its approval for use since the 1980 wasn't enough. http://www.shirecanada.com/en/shire-canada/PDF/Alertec.Product%20Mon

7ModafinilDosing
Commentr/NootropicsJan 28, 2013

Modafinil + Piracetam excitotoxicity?

Replying to [deleted] · [deleted]

>Just because there isn't any evidence demonstrating excitotoxicity doesn't mean much Please explain that statement to me. I am pretty sure that means there is no evidence that racetams exacerbate excitotoxicity, which

6NoopeptPiracetamModafinilDosing
Commentr/NootropicsDec 20, 2016

IT'S HERE!!!! P21

Replying to srubek · FTR I've had no histamine issues, personally; I'm on day 4 of dosing. Also I take armodafinil so my histamine levels are naturally higher (than they would be without modafinil), to

Good to know. I get histamine responses from being out in the cold, or just sitting doing nothing. So me having a histamine response is not indicative of the general population.

3P21ModafinilDosing
Commentr/NootropicsAug 20, 2014

Hydrafinil - New Modafinil Analogue

Replying to Bateau55 · >As shown in Table 1, subsequent screening in wake promoting assay in rats, compound 3 (100 mg/kg ip) was found to be active. Thus, it is likely that the wake promoting activity of

I should have said was considering it. They've moved to a new analog that is more efficacious. We should be getting that one in too, once we work out the synthesis issues. This is just the first one we were able to get s

3ModafinilDosing
Commentr/NootropicsFeb 23, 2014

Tianeptine from nootropicsdepot.com

Replying to jjhurley · This stuff is dangerous. Many people have gone to doses over 100mg several times a day and had as much trouble kicking it as an opiate habit. Enjoy but be very careful.

Anything is dangerous in too high of amounts. 100mg is not a smart dose, just like a gram of modafinil is not a smart dose. The same goes for caffeine and even water. That does not mean it is inherently dangerous. That j

3TianeptineModafinilDosingCaffeine