Comment · Mon, January 28, 2013 · Ceretropic
Modafinil + Piracetam excitotoxicity?
Original post in this thread
FlyingWhales80 · 25 points
I have heard many accounts of how mixing amphetamines (i.e. adderall) with piracetam is dangerous due to the probability of excitotoxicity, where NMDA receptors are overworked and essentially die.
My question is whether or not there is reason to believe that the same thing could happen between Modafinil (not a traditional stimulant) and Piracetam (or any racetam, for that matter). Modafinil partially has its effects through dopamine and norepinephrine, just like amphetamines, so I'm curious if there is the same risk involved.
What they were answering
[deleted] · -5 points
[deleted]
u/MisterYouAreSoDumb · Ceretropic
Just because there isn't any evidence demonstrating excitotoxicity doesn't mean much
Please explain that statement to me. I am pretty sure that means there is no evidence that racetams exacerbate excitotoxicity, which is what I stated.
Those studies you cited are garbage, btw.
Again, you must explain yourself.
Fact of the matter is, your subjective experience is your best gauge.
That is entirely false, and completely against any scientific method. You cannot "feel" excitotoxicity. Explain to me what excess calcium influx through your NMDA channels feels like. Explain to me what NMDA and AMPA receptor down-regulation feels like. You can't, and you certainly wouldn't be able to pinpoint the cause if you could.
I've felt periods of extreme brain fog and other radical symptoms when dosing of AMP + piracetam was too high.
Brain fog is not excitotoxicity, nor should it be used as a gauge of a substances glutaminergic effects.
I'm glad you found the sweet spot that works for you. However, that is irrelevant to the discussion we were having. There is evidence that NMDA and AMPA modulators like piracetam and noopept provide neuroprotection from glutamate toxicity. I have given you some links, but there are more. You have given me no evidence refuting that, nor have you given me evidence that they exacerbate glutamate toxicity. Your only addition is an anecdotal report of brain fog with amphetamines and piracetam.