Comment · Thu, August 15, 2013 · Ceretropic
Bacopa
What they were answering
flowstatejunkie · 1 points
I'm wondering why you say that bacopa stacks well with caffeine? When bacopa regulates dopamine spikes, thus reducing caffeine's effect.
u/MisterYouAreSoDumb · Ceretropic
Are you suggesting that caffeine's main benefit is increased dopamine? Caffeine's effects are andenosine mediated, which affects many systems. The wakefulness from caffeine does not come from DA spikes, so bacopa is not reducing it's effectiveness in that regard. It's perfect for balancing out the adverse effects of caffeine.
http://www.sciencedirect.com/science/article/pii/S0378874107000438
Treatment with BM (40 and 80 mg/kg) attenuated the stress induced changes in levels of 5-HT and DA in cortex and hippocampus regions but was ineffective in normalizing the NA levels in AS model, whereas PQ treatment significantly reverted back the effects of stress. In CUS model, pretreatment with BM and PQ significantly elevated the levels of NA, DA and 5-HT levels in cortex and levels of NA and 5-HT in hippocampus regions. Hence, our study indicates that the adaptogenic activity of BM might be due to the normalization of stress induced alteration in plasma corticosterone and levels of monoamines like NA, 5-HT and DA in cortex and hippocampus regions of the brain, which are more vulnerable to stressful conditions analogous to the effects of PQ.