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Comment · Wed, August 14, 2013 · Ceretropic

Sunifiram and nicotine

Original post in this thread

Tomas60 · 10 points

I read somewhere that nicotine is an acetylcholine agonist. I didn't feel good when I tried sunifiram and smoked cigarettes. Does acetylcholine agonist mean that it shouldn't be used with sunifiram?

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic

Sunifiram seems to potentiate ACh agonists, and other stimulants. So be careful mixing them. Someone on Longecity already went to the hospital because he mixed high doses of caffeine with high doses of sunifiram.

Sunifiram is an AMPA positive allosteric modulator. This will increase the transmission of glutamate through the NMDA channels, and can cause over-stimulation when taken with stimulants that also increase glutamate.

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