Comment · Wed, April 17, 2013 · Ceretropic

Is modafinil tolerance reversible?

Original post in this thread

DelusionalVirtuoso · 9 points

I was wondering if anyone here has had experience with modafinil Torrance. Can it ever go back to the level that it was when you first took it, and if so, how long does it take?

I have only recently just started taking it, but I'm afraid I may have permenantly damaged my tolerance by binging on 800mg.

What they were answering

deh707 · 7 points

I hear Milk Thistle reduces tolerance, as it has to do with liver enzymes.

u/MisterYouAreSoDumb · Ceretropic

Ohh, that's actually a good idea. Perhaps not milk thistle specifically. However, maybe most of the noticeable tolerance is simply due to CYP450 enzyme induction. Returning the enzymes to normal levels might eliminate most of the perceived tolerance.

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