Comment · Tue, April 16, 2013 · Ceretropic
Discussion: nootropics/supplements that aid the prevention or reverse the neurotoxic/cardiotoxic effects of Adderall
Original post in this thread
Smackugood · 29 points
Just wanted to pool everyone's ideas into one thread. I got the idea from my last post when /u/waqwarrior posted about being able to reduce some of the negative effects of adderall. Can anyone else add to this short list or include sources for the ones already here? Also I realize that this list isn't for everyone but for those that do take it I think it would be helpful. Secondly, I am interested in reversal of negative effects because I am quitting tonight and would like to know my options. Thanks!
From his post:
>It is a fact that amphetamine is a powerful stimulant, though. This will increase the firing of glutamatergic receptors. Glutamate is an excitatory neurotransmitter. An overabundance of glutamate firing can lead to cell death, which is the last thing you want. L-Theanine mildly blocks NMDA and kainate receptors, which give it mildly neuroprotective effects - it's preventing (or at the least lessening) the negative effects of overexcitation. It also boosts GABA production; GABA is inhibitory, essentially glutamate's opposite (though it functions much differently, this comparison works for a simple explanation).
The type of stress your cells are under is often referred…
What they were answering
NeedMoreLSD · 1 points
I was having a discussion with someone about selegiline and its bi-products, namely levomethamphetamine which is inactive to the central nervous system and my friend pondered that levomethamphetamine is inactive as it is impermeable to the BBB and thus safe which is why it can be used in products like Vix vapo rub without being meth. However selegiline does cross the BBB and could thus break down into levomethamphetamine, or at least that is the logic strain. I could not find much data on what makes levomethamphetamine the inactive form, whether it is really impermeable at the BBB or if it is inactive on the receptors itself. I was hoping you could shed some light on this?
u/MisterYouAreSoDumb · Ceretropic
Selegiline is metabolized in the periphery by N-dealkylation, beta-carbon hydroxylation, and ring-hydroxylation. This means that all metabolites are only present in the periphery, and ones that cannot cross the BBB are still inactive.