How long prior to MDMA should you take your pre-load? (multivitamins, magnesium and antioxidants)

Comment · Thu, December 27, 2012 · 22 pts

**-Fully chelated magnesium glycinate.** Doctor's Best brand is good. Most brands are shit. (Dose 400mg before and during) **-Alpha lipoic acid.** You can either get racemic ALA, which is still good. Or you can get full

Comment · Thu, December 27, 2012 · 13 pts

**NO!** It inhibits metabolism by CYP3A4, which uses N-demethylation to produce MDA. MDA is **MUCH MUCH** more neurotoxic than MDMA. You should absolutely drink grapefruit juice! MDMA's neurotoxicity is a direct result

Comment · Thu, December 27, 2012 · 3 pts

In MDMA's case, it should absolutely be used! Higher MDMA serum levels are much safer than it's toxic metabolites. Read my post here: http://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neurotoxicity_part_1_metaboli

Comment · Thu, December 27, 2012 · 6 pts

Metabolism of MDMA to MDA in humans is anywhere from 5% to 18%, depending on dosage, re-dosing schedule, body temperature, and a couple other factors. Rats metabolize much more to MDA, due to their CYP2D1 (Their CYP3A4

Comment · Fri, December 28, 2012 · 1 pts

Yes, that will be the only way to prove it. Know anyone? Haha

Comment · Fri, December 28, 2012 · 2 pts

It helps to clear up any spaced out feelings. Forgetfulness and such. It's not necessary if you have nothing to do. If you want to increase focus, then it helps.

Comment · Fri, December 28, 2012 · 3 pts

I take CoQ10, but I have yet to try idebenone. When do you take it, and what is your dose?

Comment · Fri, December 28, 2012 · 5 pts

I'm 27, and I only take it every 4-6 months. However, I always take my supplementation. I am telling you guys, it works. I have zero comedown, zero clenching, I can pee, and I have a 2 week long afterglow. My supplementa

Comment · Fri, December 28, 2012 · 2 pts

Correct. But I have spoken to it on other posts, it kills the empathy of the experience. I do not like the feeling of MDMA on any of the racetams. I tried it with noopept last week. It was soooo intense, and all the empa

Comment · Sat, December 29, 2012 · 2 pts

Indeed it is. My comment was more to do with your statement, " I space out my rolls by doing it only like once or twice a year and only really snag some 5HTP after the fact. The rest of this all sounds like some sketchy

Comment · Sat, December 29, 2012 · 3 pts

I never said skepticism was unwarranted. I was calling into question your wording. You have a strange way of trying to engage in productive conversation. I even said: >If that's not the case, I apologize. I was on my p

Comment · Sat, December 29, 2012 · 3 pts

There's no point in arguing semantics. We'll get nowhere. The piracetam was in there because I just copied this from another one of my posts. It does have neuroprotective properties as well, so it's inclusion it's not t