Comment · Thu, December 27, 2012
How long prior to MDMA should you take your pre-load? (multivitamins, magnesium and antioxidants)
Original post in this thread
[deleted] · 18 points
I have several vitamins, antioxidants and magnesiun supplements but I wonder when I should take them. 1h prior? 30mins prior?
What they were answering
yayblah · -5 points
Do not take grapefruit juice before dosing with MDMA... Grapefruit juice slows metabolism (via CYP3A4 inhibition) of MDMA and could lead to too high levels of MDMA.
Edit: reworded what I meant so you guys don't jump down my throat again
u/MisterYouAreSoDumb
NO!
It inhibits metabolism by CYP3A4, which uses N-demethylation to produce MDA. MDA is MUCH MUCH more neurotoxic than MDMA. You should absolutely drink grapefruit juice! MDMA's neurotoxicity is a direct result of it's metabolites. If you could completely stop all metabolism, that would be ideal.
WE DO NOT WANT MDMA's METABOLITES!
Will it affect your serum levels of MDMA? Absolutely, and you should be aware of that. However, that is a good thing.
Please don't tell people not to do something unless you fully understand the mechanisms for toxicity of a substance.