Skip to content

Comment · Thu, December 27, 2012

How long prior to MDMA should you take your pre-load? (multivitamins, magnesium and antioxidants)

Original post in this thread

[deleted] · 18 points

I have several vitamins, antioxidants and magnesiun supplements but I wonder when I should take them. 1h prior? 30mins prior?

What they were answering

yayblah · -5 points

Do not take grapefruit juice before dosing with MDMA... Grapefruit juice slows metabolism (via CYP3A4 inhibition) of MDMA and could lead to too high levels of MDMA.

Edit: reworded what I meant so you guys don't jump down my throat again

u/MisterYouAreSoDumb

NO!

It inhibits metabolism by CYP3A4, which uses N-demethylation to produce MDA. MDA is MUCH MUCH more neurotoxic than MDMA. You should absolutely drink grapefruit juice! MDMA's neurotoxicity is a direct result of it's metabolites. If you could completely stop all metabolism, that would be ideal.

WE DO NOT WANT MDMA's METABOLITES!

Will it affect your serum levels of MDMA? Absolutely, and you should be aware of that. However, that is a good thing.

Please don't tell people not to do something unless you fully understand the mechanisms for toxicity of a substance.

Other MYASD lines in this thread

Related in the archive

Postr/DrugNerdsDec 29, 2012

MDMA Supplementation

Ok, I did promise that I would make another post regarding supplementation to mitigate MDMA induced neurotoxicity. I have just been putting it off. Since my last post, I have gathered more information regarding my theory

205270MagnesiumDosing
Commentr/DrugsNov 8, 2012

Research Suggests no Neurotoxicity in MDMA

**I'm going to copy what I wrote on another thread:** _____________________________________________________ YES! Keep your damn body temperatures down people! http://www.maps.org/publications/1998_malberg_1.pdf http:

597PiracetamMagnesiumQuercetinDosing
Postr/NootropicsJul 18, 2023

Independent Lab Testing Results Of Supplements On The Market

Hey everyone, it's been a while since I have made a post in this sub. However, I saw a new research study today that I wanted to bring up. It highlights why my main mission over the past 10 years has been to not only adv

402152Dosing
Postr/NootropicsDepotJul 18, 2023

Independent Lab Testing Results Of Supplements On The Market

Hey everyone, I saw a new research study today that I wanted to bring up. It highlights why my main mission over the past 10 years has been to not only advance the lab testing and quality control standards of the indust

20422Dosing
Postr/SupplementsJul 18, 2023

Independent Lab Testing Results Of Supplements On The Market

Hey everyone, I've never actually posted in this sub. However, I saw a new research study today that I wanted to bring up. It highlights why my main mission over the past 10 years has been to not only advance the lab tes

15626Dosing
Postr/NootropicsNov 27, 2013

Cerebral Health Pyritinol (New Test Results)

We have finally identified the substance that Cerebral Health was selling as pyritinol, which has sent one person to the hospital, and caused adverse reactions in half a dozen other people so far. The results are very su

13776Dosing