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Comment · Thu, December 27, 2012

MDMA 'eases post-traumatic stress':

What they were answering

morbidgoldfish · 33 points

MDMA doesn't give you depression. It depletes your serotonin due to the intense high, causing you to feel depressed or whatever. Depression is more encompassing than that.

u/MisterYouAreSoDumb

What you are describing in down-regulation of the 5-HT receptors. This is a different mechanism to serotonin depletion. MDMA also lowers your body's ability to produce serotonin.

The two ring-hydroxylated metabolites of MDMA and it's metabolite, MDA, 2,4,5-trihydroxyamphetamine (THA) and 2,4,5-trihydroxy-N-methylamphetamine (THM), both reduce tryptophan hydroxylase levels (TPH). This is the substance your body uses to turn tryptophan into 5-HTP, which is then converted into serotonin. THA in particular can lower TPH levels by 90% after 7 days! It slows your body's ability to produce serotonin for a couple weeks.

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