Comment · Thu, December 27, 2012

MDMA 'eases post-traumatic stress':

What they were answering

[deleted] · 2 points

since you're a biochemist, can you answer me this? I heard 5-htp taken in pill form is bogus because the substance never breaks the blood brain barrier, and it actually has negative effects on your heart (pill form 5htp, that is). any truth to this you think?

u/MisterYouAreSoDumb

No, that is incorrect. 5-HTP readily passes the blood brain barrier. However, it also readily converts to serotonin in your periphery by the enzyme aromatic L-amino acid decarboxylase. This is bad because serotonin, or 5-HT, cannot pass the blood brain barrier. This means that you are wasting your 5-HTP. Also, elevated serotonin levels in your periphery can cause heart valve damage. This is why everyone should ALWAYS take EGCG with their 5-HTP. EGCG is an aromatic L-amino acid decarboxylase inhibitor. This will prevent it's metabolism to 5-HT until it has a chance to pass your blood brain barrier.

Other MYASD lines in this thread

Related in the archive

Commentr/scienceDec 26, 2012r/Nootropics years

Engraved stone dating back 30,000 years found in China. Incisions imply possibility of counting or recording?

Replying to [deleted] · From an evolutionary view we are pretty much the same people today as we were then. They were still smart just didn't have all the accumulated knowledge we have today.

They had the similar potential, but development of neuronal connections is dependent on learning and usage. Since they weren't subject to nearly the same level of stimuli during their development, their intellectual capa

195

Commentr/scienceSep 30, 2012r/Nootropics years

Women with endometriosis tend to be more attractive

Replying to [deleted] · [deleted]

In my scientific Google study, I can confirm the article's findings. [With](https://www.google.com/search?hl=en&safe=off&q=women+with+endometriosis&bav=on.2,or.r_gc.r_pw.r_qf.&biw=1600&bih=762&um=1&ie=UTF-8&tbm=isch&sou

153

Commentr/scienceJul 18, 2023Enforcement & plea

Nearly 90% of herbal sports supplements are mislabeled. One in ten contain prohibited substances | The labels of sports supplements are not what they seem to be.

Replying to rdesktop7 · Because those CEOs are not breaking any laws. You can put sugar pills in a bottle, and call it anything you want as long as it's listed as a "supplement".

That's not true. Label claims and concentration are absolutely regulated. [Read 21 CFR 111](https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-111). All supplements have to be at or above label claim, with

119

Commentr/scienceMay 7, 2012r/Nootropics years

When people exercise aerobically, their bodies can actually make drugs — cannabinoids, the same kind of chemicals in marijuana.

Replying to threeminus · Based on my research, I'd say optimal order is run -> smoke -> shower.

run -> smoke -> shower -> smoke -> eat FTFY

Commentr/scienceAug 13, 2013r/Nootropics years

People may feel more empathy for dogs than for some of their fellow humans

Replying to [deleted] · [deleted]

I hope eventually you realize that cautionary logic, and trust for those around you, are not mutually exclusive. People are stupid, emotional, under-informed, over-reactionary, and generally ignorant. However, they are a

Commentr/scienceSep 27, 2012r/Nootropics years

MDMA may help in depression and PTSD, study suggest. Taboo surrounding substances prevents further research. [THE GUARDIAN]

Replying to _angel · It depends how strong the dose is. It takes 2 months from someone who has no serotonin in their system to go to full, kind of like filling up a water tower. However, if someone t…

That's such a massive oversimplification. There is absolutely no way to measure amounts of serotonin depletion in live subjects. Also, the rate at which it is replenished is dependent on many variables, like the amount o