Would micro-dosing MDMA on a daily basis be viable from a psychotherapy standpoint (anxiety, social lubrication, etc.) or does it's method of action and neurotoxicity prevent such use?

Comment · Thu, December 20, 2012 · 13 pts

MDMA itself does not inhibit 5-HT production. That is caused by it's two ring-hydroxylated metabolites, 2,4,5-trihydroxy-N-methylamphetamine (THM), and 2,4,5-trihydroxyamphetamine (THA). Coincidentally, dose and body tem

Comment · Thu, December 20, 2012 · 9 pts

This is a question that is hard to answer, given our current knowledge. There have been many anecdotes that small below-threshold doses of MDMA actually potentiate a full dose of MDMA. The mechanism for which is not unde

Comment · Thu, December 20, 2012 · 3 pts

As do I. I am curious about the mechanisms behind their effects on up/down-regulation, though. Below-threshold doses of MDMA potentiating a roll is a interesting effect.

Comment · Thu, December 20, 2012 · 5 pts

Usually people have tried a below-threshold dose the night before, or morning of. The anecdotes have indicated that it definitely potentiated the roll. I have yet to try it myself, though.

Comment · Fri, December 21, 2012 · 2 pts

Yes, like hypericin does. It would be interesting to know exactly why this happens, though. To my knowledge,nobody is sure what mechanism leads to the up-regulation. Also, CYP2D6 inhibition may play a role as well.