Comment · Thu, November 29, 2012 · Ceretropic
Why isn't DXM a more popular nootropic?
Original post in this thread
[deleted] · 0 points
Not in high doses, mind you, but I get a very "head-spacey clarity" and extreme mental alertness from doses 100-200mg. (Anything higher than 400 I've found dissociative)
Usually reserve it for times of high mental stress to avoid building up a tolerance.
What they were answering
thelurkingdead · -5 points
Regardless, to be a nootropic, a substance has to be non-toxic.
Says who? This is a great example of the type of uneducated armchair Pharmacology that goes on in this sub. The LD50 of Vinpocetine, for instance, is said to be 502mg/kg. Nicotine can kill at 0.5–1.0 mg/kg.
u/MisterYouAreSoDumb · Ceretropic
Call me an uneducated armchair pharmacologist all you want, but you are wrong!
To be considered a nootropic, a substance must:
Exhibit few side effects and extremely low toxicity, while lacking the pharmacology of typical psychotropic drugs (motor stimulation, sedation etc.).
This was a criteria from Dr. Corneliu E. Giurgea, the person who came up with the term. If you don't like it, then use another term.
Nicotine is not a nootropic, as it has well known side effects and is extremely toxic. It's listed as a poison for fucks sake! http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0003148/
Vinpocetine has very few side effects and low toxicity. http://www.ncbi.nlm.nih.gov/pubmed/2272713
Dextromethorphan is a psychoactive dissociative! It's an uncompetitive NMDA receptor antagonist, has μ-, δ-, and k-opiod affinities, as well as being a 5-HT and NE reuptake inhibitor! It can cause serotonin syndrome! IT'S NOT A NOOTROPIC!!!
http://www.ncbi.nlm.nih.gov/pubmed/7562497
http://www.ncbi.nlm.nih.gov/pubmed/19238739
http://www.ncbi.nlm.nih.gov/pubmed/16051647
http://www.ncbi.nlm.nih.gov/pubmed/18812887
So I don't know what kind of armchair you are currently sitting at, but your argument is baseless and significantly less cited than mine.