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Comment · Sat, November 10, 2012

Research Suggests no Neurotoxicity in MDMA

Original post in this thread

PuffyCheek · 194 points

In partial response to what I've been reading in the bestof'd thread here at /drugs, I think it would be good to start a discussion about the neurotoxicity in MDMA.

I feel as if the harmful effects discussed in the thread were overblown. According to a research done by the Harvard Medical School last year in 2011, users who were asked to use MDMA under a controlled setting over a certain period of time showed no signs of cognitive impairment nor decreased mental ability.

So the question remains, why do we have so much evidence from past research studies that show otherwise? The researchers at Harvard Medical School responded by saying that past research studies lacked a proper control environment. What that means is that past research studies did not control their test group to make sure they didn't engage in unhealthy activities after ingesting MDMA (i.e. going to a rave and dancing for 8 hours straight).

No research since 2011 has proved Harvard Medical School's conclusion wrong, that MDMA is actually harmful to your brain. No other research studies that I could personally find had settings as controlled as the one conducted by HMS.

That being said, research was done…

What they were answering

rumckle · 2 points

Buy some piracetam. It is a neuroprotectant, and it potentiates your roll. If you don't take it before, take it before bed.

Specifically piracetam, or would other racetams work?

u/MisterYouAreSoDumb

It really depends on which racetams you are talking about. Aniracetam is going to be more of an AMPA receptor allosteric modulator than an NMDA. Oxiracetam works, but enhances sound like crazy. It's too overwhelming for a music event. The treble is too much to handle sometimes. Pramiracetam is too strong, and increases NOS in the brain. I wouldn't suggest that. I have not tried noopept, but there are not as many pharmacological studies to go on. I'd personally stick to piracetam. However, I will mention that is mostly for people with a tolerance. If you do not have a tolerance, stick to taking racetams the week after your roll.

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