Comment · Tue, January 27, 2026 · ND Owner
Alcohol Question - Supplements to Prevent the Damage?
Original post in this thread
GeuseyBetel · 13 points
I’m looking for a stack to take \before\ drinking to mitigate its damaging effects as much as possible (even at the cost of feeling a buzz). I respect the experience/opinions of this community so I’m looking for insights here.
Let’s just say you \have\ to drink at an occasion, what are the best supplements to take ahead of time?
I’m aware of ND’s Alcohol Defense, but under its Suggested Use it says:
\”DO NOT take Alcohol Defense before drinking, or it may interfere with your ability to feel the effects of alcohol.”\
Does that mean if it’s taken before, it will aid with preventing the damage?
I’m familiar with things like NAC - are there other supplements along a similar vein that anyone here would recommend?
What they were answering
RarageInTheGarage · 1 points
Phenylacetyl glutathione is a tad more favored towards the liver and peripheral effects due to its molecular weight vs acetyl, right?
u/MisterYouAreSoDumb · ND Owner
Without direct pharmacokinetic data, that is hard to say. I can say it certainly has different pharmacokinetics than normal reduced glutathione or S-acetyl glutathione. This means it will reach different parts of the body in different amounts. Saying for sure it will reach the liver and peripheral areas more than central, without data to prove it, isn't really warranted. Noopept has a phenylacetyl group, and it reaches the brain. We can speculate phenylacetyl glutathione might as well, but it's just speculation till we get some pharmacokinetic studies.