Comment · Mon, December 22, 2025 · ND Owner
Alcohol Question - Supplements to Prevent the Damage?
Original post in this thread
GeuseyBetel · 13 points
I’m looking for a stack to take \before\ drinking to mitigate its damaging effects as much as possible (even at the cost of feeling a buzz). I respect the experience/opinions of this community so I’m looking for insights here.
Let’s just say you \have\ to drink at an occasion, what are the best supplements to take ahead of time?
I’m aware of ND’s Alcohol Defense, but under its Suggested Use it says:
\”DO NOT take Alcohol Defense before drinking, or it may interfere with your ability to feel the effects of alcohol.”\
Does that mean if it’s taken before, it will aid with preventing the damage?
I’m familiar with things like NAC - are there other supplements along a similar vein that anyone here would recommend?
What they were answering
mbvlover25 · 6 points
NAC, Milk Thistle & Tudca
u/MisterYouAreSoDumb · ND Owner
The same goes for NAC. You have to take NAC before drinking alcohol, or it makes the damage worse. It's because of a dual stage pharmacokinetic profile that results in toxic metabolites being made by NAC if alcohol is already in your system, where that metabolic pathway is avoided if the NAC was in your system before the alcohol. Because of this, I usually just tell people to take glutathione or S-acetyl glutathione before drinking to simplify it.