Comment · Mon, August 22, 2022 · ND Owner
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NDSocialMedia · 50 points
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What they were answering
9qQ7oiJpPmjZ4F · 2 points
I'm far more concerned about neuropathy. I used to drink 2-3 monster drink zeros a day, and I started getting neuropathy issues in my toes, which of course I have not been able to reverse. Now I just drink one in the morning, but even that's probably too much.
>Vitamin B6 toxicity symptoms mimic vitamin B6 deficiency. The classic presentation of pyridoxine toxicity is peripheral sensory neuropathy. It is helpful to obtain a thorough history and ask about supplements and dosages. Vitamin B6 toxicity is seen with vitamin supplements but not from dietary intake of foodstuffs.
https://www.ncbi.nlm.nih.gov/books/NBK554500/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483950/
Vitamin B6 4.0mg (286% RDA) PER CAN!!!!
u/MisterYouAreSoDumb · ND Owner
Well that's an issue with pyridoxine, but not P5P. So the two situations are different. Taking higher doses of pyridoxine actually lowers P5P levels, due to the salvage pathway. The prevailing theory is that is lowering GABA production, which is causing the toxicity that leads to neuropathy.
https://academic.oup.com/advances/article/12/5/1911/6257780
This is why I always say that P5P is the only form of B6 people should be supplementing. The bone mineralization thing is a totally separate mechanism that does seem to be relevant to P5P.