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Comment · Thu, August 18, 2022 · ND Owner

⚠️ NEW PRODUCTS ALERT | Pyridoxal-5 Phosphate Capsules, S-Acetyl L-Glutathione Capsules & Powder, & Astragaloside IV Capsules⚠️

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NDSocialMedia · 50 points

What they were answering

TheOptimizzzer · 25 points

Nice, an astralgus product has been a long time coming! A bit expensive, but cool!

Any anecdotes from ND employee users/testers?

Anyone willing to guess on magnitude of anti-aging effect vs something like OptiNAD? Would you include it in an optimal cost-benefit adjusted geroprotective stack?

u/MisterYouAreSoDumb · ND Owner

We are doing more astragalus products. This is just the first one. It's also the cheapest per mg astragaloside IV on the market at the moment. So more expensive than normal astragalus for sure, but the cheapest for astragaloside IV. It's also way more astragaloside IV than you will get with any normal astragalus extract out there, so a very different specialized thing.

Regarding effects, I actually liken it to the effects you get from 1,000mg L-carnosine. It feels very similar. It hits AMPK and lowers lipid accumulation, so it is really good for cardiovascular function and weight control. It's slightly stimulating, especially as part of my stack that already is hitting AMPK. It's a really cool one!

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation

Astragaloside IV Improves High-Fat Diet–Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

Then of course you have the telomere lengthening and anti-aging effects.

Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis

The Effect of the Geroprotectors Astragaloside IV, Cycloastragenol, and Timovial–Epivial Peptide Complex on Telomere Length and Telomerase Activity in Human Mesenchymal Stromal Cells and Senescent Fibroblasts

It's one I have added into my daily routine now.

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