Comment · Fri, December 31, 2021 · ND Owner
The subreddit itself is proof nootropics work
Original post in this thread
stevenchamp45 · 11 points
This just came across my mind, but this is the only Subreddit that I've ever came across (besides maybe r/Nootropics) that isn't toxic at all, no arguments, no mean people, no internet intellectuals, and at the same time everyone here is always kind, receptive, clear-headed, and open-minded. Considering this is reddit, that's damn near impossible. So clearly, the people of this subreddit are, to say, "getting high on Nootropic Depot's supply"😊, I mean shoot, the suburb is leaps and bounds more peaceful than even r/Meditation
What they were answering
Anticode · 3 points
It's unrelated to the topic at hand, but what are your modern thoughts of NMDA agonists for cognitive/emotional enhancement?
I recall that you did some casual testing of dextromethorphan Hbr (DXM) in this vein several years ago (I'm not sure why I recall the comment so vividly). A year or two after that is when the Big Dawg ketamine research started reaching the public eye and that only validated my later decision to also investigate OTC NMDA agonists after seeing your interest.
Is that something you still find value in as part of your stack or as a spot-fix?
As an aside, I did later get ahold of street-tier ketamine which was then used to approximate a quasi-clinical treatment plan at home. I found astounding success there; yet another validation of NDMA as a viable target for interactions.
Is there anything new and nifty on the horizon or within the nootropics ecosystem that tickles those receptors, perhaps?
u/MisterYouAreSoDumb · ND Owner
I think a lot of the beneficial cognitive effects from things that bind to the NMDA receptor are actually from other mechanisms that happen to go alongside the NMDA antagonism. These mechanisms would be sigma-1 agonism and modulation of the glycine receptors. I do think DXM can be a useful tool, but I think that is from the sigma-1 effects, not the NMDA effects. We have been doing R&D to bring out more targeted things that hit sigma-1 instead. I think saffron is interesting in that way, but most of the extracts out there are standardizing to things that hit serotonin and NMDA, whereas I think we should focus on sigma-1.