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Comment · Sun, April 25, 2021 · ND Owner

When should I dose Polygala when stacking with 4-DMA-7,8-DHF

Original post in this thread

Ax56Ax · 3 points

I have been dosing 4-DMA-7,8-DHF 8mg in the morning and it has no doubt been one of the most effective substances period I have taken for my mood, anxiety and overall wellbeing. After reading the available evidence in regards to 7,8-DHF that seems to line up. I have also seen the posts about TrkB downregulation and thus you should stack it with Polygala to avoid that.

My question is that Polygala is also said to be stimulating so how does taking it in the evening work for most people? Do you take around dinner time? I want to lose as little of the benefits as possible that I am receiving from 4-DMA-7,8-DHF.

I appreciate the insight.

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · ND Owner

Polygala is an interesting one from a sleep perspective. Tenuifolin actually promotes sleep. However, taking polygala before bed can be counterproductive for some people. I generally tell people to take it in the evening, but not too close to bed time. There are some things that improve sleep if you take them during the day, but not if you take them right before bed. Polygala seems to be one of those things for some people.

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