Comment · Thu, January 7, 2021 · ND Owner

4’-DMA-7,8-DHF 30caps now live!

What they were answering

chris106 · 6 points

u/MisterYouAreSoDumb \- I was wondering;

among a few other people in this thread, you too have mentioned Polygala for preventing hypothetical TrkB downregulation from 7,8-DHF or 4’-DMA-7,8-DHF- use.

Should the polygala be taken alongside 7,8-DHF, or should it be cycled? I've seen both options mentioned.
I can't quite wrap my head around how polygala could prevent TrkB downregulation, while at the same time not interfere with the positive effects from 7,8-DHF - if it's taken at the same time, that is.

u/MisterYouAreSoDumb · ND Owner

I would say 7,8-DHF or 4’-DMA-7,8-DHF in the morning, then polygala at night. Some people do combine them with good effects, though. The mechanisms are pretty complex, and we still have to elucidate a lot of the specifics. When you have novel things like this, it is going to take some trial and error for people to really feel out what works best with combos. I personally space the polygala and 7,8-DHF out.

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