Comment · Thu, January 7, 2021 · ND Owner
4’-DMA-7,8-DHF 30caps now live!
What they were answering
TheReckoning1323 · 6 points
okay , thankyou for the response, and i was reading that it is slightly water and fat soluble. What would you suggest would be the best absorbtion , on an empty stomach, or possibly with healthy fats like mct oil? additionally does anyone know what makes 4’-DMA-7,8-DHF have better oral availibility if it has nearly the same Logp value? thanks in advance
u/MisterYouAreSoDumb · ND Owner
Empty stomach will be best for this one.
additionally does anyone know what makes 4’-DMA-7,8-DHF have better oral availibility if it has nearly the same Logp value?
Solubility is not the issue with 7,8-DHF. Both are orally bioavailable. I guess it is not precise of me to say the improvements are due to increases in bioavailability. The dimethylamino grouping on the phenyl ring increases its agonistic activity to TrkB and prolongs its effects in the body. This study goes into detail.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150605/
So it would be more precise of me to say this is a more effective and longer-lasting compound than 7,8-DHF, due to the modifications to the phenyl ring. That study showed that both the ortho-dihydroxy groups and the oxygen atom in the cyclic ring is crucial to the BDNF-mimetic effects, so those groupings need to be there for it to work.