Skip to content

Comment · Thu, November 26, 2020 · ND Owner

Fasoracetam and GABA-B receptors recovery

Original post in this thread

3ric843 · 19 points

Hello everyone,

I see that fasoracetam is marketed as a solution to help your gaba-B receptors recover by up-regulating them. Apparently it helps with withdrawal and lowers tolerance quickly, and repairs you GABA-B receptors.

This sound very interesting to someone like me, who abused gabaergics (phenibut, GHB and alcohol mainly, but also etizolam has been sometimes taken every night for sleep for some periods) in the past and is trying to recover.

But I also read that the up-regulation only lasts while you are supplementing, and there is a rebound when you stop, similar to the one GHB or phenibut does.

So my question is, anyone know if it is just a marketing gimmick?

From my understand, it's either:

1- A healthy person takes it, GABA-B up-regulates, after cessation everything comes back to normal

2- A person with damaged / downregulated GABA-B receptors takes it for a while, it fixes and upregulates its GABA-B receptors, after cessation there is some loss of up-regulation but it stays better than before the fasoracetam cycle

3- A person with damaged / downregulated GABA-B receptors takes it for a while, it upregulates his receptor, but after cessation, everything goes back…

What they were answering

nanasitoomi · 2 points

I want to use fasoracetam and emoxypine with phenibut to get the most effect out of the smallest dose, like 250mg/day once a week. Do you have any recommendation what should be the best timing to dose the two other ? With phenibut, ingesting at the same time to enhance it, or off days to “refresh” those receptors and maybe get an extra “happy day” when just the two other working as a mild anxyolitic? Also want to minimize overall nootropic intake so would be nice if I can take faso and emoxy also max one time weekly. therefore they have “instant”, acute effect?

u/MisterYouAreSoDumb · ND Owner

I would just say emoxypine and fasoracetam in the morning on the off days to sensitize.

Other MYASD lines in this thread

Related in the archive

Commentr/NootropicsJul 13, 2016

Fasoracetam

Replying to full_silver · Do you have an idea on what the proper protocol with Fasoracetam would be to restore phenibut tolerance for a long time? I used to take phenibut 2x week spaced out, 1.6g just to ge

Phenibut is a very fickle compound. Tolerance to its effects happens in very strange manners, and is longer-term than other compounds. For Fasoracetam, I personally found results with both lower dosages multiple times a

2PhenibutFasoracetamDosingRacetams
Commentr/NootropicsDepotSep 16, 2020

Sleep support causing next morning depressed mood, pessimistic feelings questions....

>I took some NALT with P5P the mornings after, but I really didn’t notice an improvement. I just picked up some regular L-tyrosine, so I’ll try larger doses of this with P5P. Some people get much better effects from L-

11AniracetamFasoracetamBacopaTongkat ali
Commentr/NootropicsDepotFeb 3, 2021

Herbal GABAergics and dependency

Replying to umbrella_term · If I understand your last paragraph correctly, fasoracetam can help undo phenibut tolerance? Also, speaking of benzos, phenibut and GABA: do the former two interact with lemon bal

Fasoracetam modulates the metabotropic glutamate receptors, which causes a compensatory up-regulation of GABA-B receptors. GABA-B down-regulation is part of the tolerance. >Also, speaking of benzos, phenibut and GABA: d

5PhenibutFasoracetamRacetams
Commentr/NootropicsDepotFeb 16, 2019

R-ALA cyclodextrin dosing

Replying to Majalisk · Oh god, I had forgotten about sulbutiamine. I wanted to forget...I used it like once, 3 years ago or something. It’s so awful, like eating what someone would think of when they say

The cyclodextrin curcumin is on my counter in the bathroom! I have been using our sample for personal use for a while. LOL. We have a big backlog of new stuff we are bringing out. That one has been on the backburner for

1PhenibutPramiracetamDosingRacetams
Commentr/NootropicsJul 29, 2014

Fasoracetam

Replying to m00k0w · In theory from the bit I read, fasoracetam should slowly, over time, start making you give yourself a natural anxiolytic/nootropic effect by upregulating GABA receptors. You'll be

Nootropics Depot will soon. They are just testing their stuff before launching. I tried a dose of it at their offices a couple weeks ago. It seemed interesting. I started to get some weird stimulation on it, though. I ne

7PhenibutFasoracetamRacetams
Commentr/NootropicsJun 24, 2014

4 Interesting Facts about Coluracetam

Replying to FW900 · The second claim is outdated. >2) It is the first *and only known* choline-uptake enhancer. This is not true, Fasoracetam has been shown to he a high affinity choline uptake enha

As is oxiracetam. http://journals.lww.com/clinicalneuropharm/Abstract/1986/00093/Effect_of_Oxiracetam_and_Piracetam_on_Central.7.aspx A single administration of 300 mg/kg i.p. of oxiracetam and piracetam also increased

6PiracetamOxiracetamFasoracetamColuracetam