Comment · Wed, November 4, 2020 · ND Owner
Fasoracetam and GABA-B receptors recovery
Original post in this thread
3ric843 · 19 points
Hello everyone,
I see that fasoracetam is marketed as a solution to help your gaba-B receptors recover by up-regulating them. Apparently it helps with withdrawal and lowers tolerance quickly, and repairs you GABA-B receptors.
This sound very interesting to someone like me, who abused gabaergics (phenibut, GHB and alcohol mainly, but also etizolam has been sometimes taken every night for sleep for some periods) in the past and is trying to recover.
But I also read that the up-regulation only lasts while you are supplementing, and there is a rebound when you stop, similar to the one GHB or phenibut does.
So my question is, anyone know if it is just a marketing gimmick?
From my understand, it's either:
1- A healthy person takes it, GABA-B up-regulates, after cessation everything comes back to normal
2- A person with damaged / downregulated GABA-B receptors takes it for a while, it fixes and upregulates its GABA-B receptors, after cessation there is some loss of up-regulation but it stays better than before the fasoracetam cycle
3- A person with damaged / downregulated GABA-B receptors takes it for a while, it upregulates his receptor, but after cessation, everything goes back…
What they were answering
Slg407 · 1 points
fasoracetam is a GABA-B receptor antagonist, meaning it blocks it, this causes the body to overcompensate by creating more receptors, although it can help with tolerance it will generally just make withdrawal worse, it would be close to the second option you presented, it would block GABA-B, worsening withdrawal, and after it wears off the withdrawal would be reduced due to the upregulation
edit: so apparently i got hit by the misinformation trainwreck that is nootropics research, fasoracetam is not a GABA-B antagonist, its a metabotropic glutamate receptor agonist
u/MisterYouAreSoDumb · ND Owner
That is incorrect. It is not a GABAb antagonist. Its actions are mediated by metabotropic glutamate receptors. I'll make a larger post above.