Comment · Sat, February 16, 2019
R-ALA cyclodextrin dosing
Original post in this thread
Hywardhayward · 1 points
Hi,
According to Ikuta et al. in "Bioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926482/#!po=22.0588)
6g of R-ALA Cy is equivalent to only 600mg of Na-R-ALA. The reccomended dosing of R-ALA Cy according to ND is 500mg. If you see table 2 and chart 2 you can see to get the increased bioavailability benefits of R-ALA Cy still requires a larger dose of powder, I think it means more of the total powder weight is the cyclodextrin complex vs. smaller weight of sodium content of Na-R-ALA. So while the actual R-lipoic acid is better uptaken when in cyclodextrin complex, the fraction of each mg of R-a-lipoic acid in Na-R-ALA is way higher, i think only 5% is sodium, while the cyclodextrin appears to take up 90% of each mg of powder.
If you took 500mg of R-ALA Cy, you would only need 125mg of Na-R-ALA to match the bioavailability, even taking into account the 2.5x increased bioavailability of cyclodextrin form because there is just so little actual lipoic acid and so much cyclodextrin taking up space in the powder.
This means the R-ALA Cy needs to be dosed at a prohibitively expensive amount, using 10…
What they were answering
Majalisk · 1 points
Oh god, I had forgotten about sulbutiamine. I wanted to forget...I used it like once, 3 years ago or something. It’s so awful, like eating what someone would think of when they say ‘toxic chemicals.’ I don’t know which is worse, that or the Shilajit. I won’t be testing to find out again.
I’ve only really had the NA: R: ALA when mixed into drinks and just had a bit of a burning sensation in the drink. I’ve been fortunate to not burp it up. I have burped up berberine before, somehow, and that felt like battery acid in my throat.
Yeah, haven’t had issues with cyclodextrin form at all. This reminds me! Where is the cyclodextrin Curcumin you were thinking of? Guessing just backburner still.
That sounds truly goddamned awful.
I just mixed legion’s green mix açaí flavor (awful, never buy it, only buy the original flavor), like 2 sticks of strawberry lemonade crystals, some green apple BCAAs, and then a scoop of banana protein together.
My tongue couldn’t understand which part of it tasted worse, so it just had ‘taste,’ overpowering it. Wouldn’t exactly recommend.
u/MisterYouAreSoDumb
The cyclodextrin curcumin is on my counter in the bathroom! I have been using our sample for personal use for a while. LOL. We have a big backlog of new stuff we are bringing out. That one has been on the backburner for a bit.
I've tasted some nasty things. I am pretty desensitized to it now. I can just mix shilajit into my morning drink mix without issue now. I fast, so I only use water and no flavoring. I won't mix sulbutiamine or pramiracetam into a drink, though. Those are too bad. Pyritinol is bad as well, since it is a dihydrochloride salt. So it's like double as bad as phenibut HCL!