Comment · Sun, September 28, 2014 · Ceretropic
What they were answering
Lyle_Cantor · 1 points
Gwern, have you done any experiments with Semax, P21 or any of the other ~~Russian~~ peptides?
u/MisterYouAreSoDumb · Ceretropic
Hey hey, P21 is not Russian!
Comment · Sun, September 28, 2014 · 8 pts
I have typed out my sublingual case many times now. At 9.8% oral bioavailability, Gwern's highest dose is only roughly 5mg. That's half the dosage I use sublingually. His 12mg oral dose is almost nothing. Can't neglect t
Comment · Mon, September 29, 2014 · 2 pts
You're completely ignoring the complex pharmacodynamics of noopept. Of course high oral doses are going to lead to more side effects, with less of the wanted effects. That is because the metabolites are still active, but
Comment · Mon, September 29, 2014 · 5 pts
There are no studies investigating sublingual administration of noopept, and the relative bioavailabilities compared to oral/injection. Yes we are making a jump, albeit an educated jump. We know that sublingual bypasses
Comment · Mon, September 29, 2014 · 2 pts
We can certainly make you a solution that masks the taste. That is not hard at all. And I was not speculating out my ass. Your lowest dose of 12mg is almost nothing, when you take into account the oral bioavailability. Y
Comment · Tue, September 30, 2014 · 2 pts
> I suspect you can't and if you try, the blinding index will show blinding failed and the subject learned to distinguish even with whatever you add to try to mask the flavor. Well I will consider you the expert on flav
No!!!! You can't just say, "Ohh, the active sequence in P21 is DGGL, so let's just sell powdered DGGL!" Pharmacodynamics do not work like that! That would be like saying, "Ohh dopamine is good. Let's sell powdered dopami
Replying to Debonaire_Death · Well, certainly not a cleansing spray like Xclear, which I am recommending! If you mixed your drugs in a cleansing spray, it would wash them out of your nose with all of your gunky…
We made some a while back. I kind of just got sidetracked by other things. If people want them enough, we can certainly offer them. We have everything needed.
Replying to Aket-ten · I'm still a bit confused on the actual benefits of P21, would you say it improves memory?
It promotes neurotransmitter synthesis and neurite outgrowth. So basically it can help repair damage in the brain, and enhance transmission between neurons. It acts on CNTF, whereas things like Noopept act on BDNF. P21,
Replying to georgiob · u/MisterYouAreSoDumb recalling said that it's better to keep the peptides in the fridge but once reconstituted they have to be out to normal room temp. is that true that they degra…
Always keep peptide in the fridge, as that is where they are most stable. They are MORE stable as a lyophilized powder in the vial, and become LESS stable once you mix them with water. However, some smaller sequence pept
There is some really cool stuff now that may be doing just that. I took my first dose of SR9009 today. That is a Rev-ErbA agonist, which reverses mitochondrial damage, and even creates new mitochondria in cells. It has b
1) N-Acetyl Selank's anxiolytic mechanism is related to its ability to inhibit enkephaline-degrading ezymes. That increases the levels of your body's natural opioids. That inhibition modulates the dopaminergic system, an