Comment · Wed, May 27, 2020
Has ND ever looked into Cissus Quadrangularis?
Original post in this thread
TheOptimizzzer · 16 points
Curious as it seems this could be a herb with quite wide ranging benefits (not so much nootropic but potentially anti aging). Various studies have investigated the herb for bone regrowth/healing, joint pain, bone density, muscle growth, among other effects with mixed results. However, there seems to be a lack of understanding of what the mechanisms are and what should be standardized for in extracts, along with a lack of reputable supplement makers offering a product.
Just thought this could be in your wheelhouse! Any thoughts are appreciated.
What they were answering
sirsadalot · 1 points
Is it physically impossible for bones to grow beyond normal limits with a substance? I've heard that it may be possible with human growth hormones, I'm wondering if this is a similar case. Sorry for the over-imagination, the thought is just intruiging to me.
Also, I've heard it's theorized that the estrogenic effects were responsible for the bone growth. Would you say that's accurate? Also, why does it relieve pain?
Another thing, why does berberine cause a release in serotonin and dopamine? Is there a non-cancerous substance that is similar, and on a related note, does the effect have anything to do with it affecting the "o" receptor like phenylpiracetam does?
These questions really keep me up at night.
u/MisterYouAreSoDumb
Is it physically impossible for bones to grow beyond normal limits with a substance? I've heard that it may be possible with human growth hormones, I'm wondering if this is a similar case. Sorry for the over-imagination, the thought is just intruiging to me.
Ehh, that depends. There are mechanisms in place to stop that, but some people have disorders that make that go out of whack.
https://en.wikipedia.org/wiki/Osteochondroma
https://en.wikipedia.org/wiki/Fibrodysplasia_ossificans_progressiva
https://en.wikipedia.org/wiki/Proteus_syndrome
Also, I've heard it's theorized that the estrogenic effects were responsible for the bone growth. Would you say that's accurate? Also, why does it relieve pain?
Could be. We still don't know for sure. Could be due to osteopontin protein.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800385/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784127/
Another thing, why does berberine cause a release in serotonin and dopamine? Is there a non-cancerous substance that is similar, and on a related note, does the effect have anything to do with it affecting the "o" receptor like phenylpiracetam does?
Sigma receptors are likely at play.
https://www.sciencedirect.com/science/article/abs/pii/S0014299908005694
Berberine also up-regulates BDNF expression.
https://www.sciencedirect.com/science/article/abs/pii/S0304394016300027