Comment · Wed, May 20, 2020 · Natrium Health & Nootropics Depot
Successfully switched from 100mg Zoloft(ssri), to 25mg Zembrin(natural ssri/pde4i), and LD saffron (anecdotal case report)
Original post in this thread
gitfetchmorecoffee · 95 points
I have been on zoloft for around two years, and while it has been effective for depressive thoughts, the cognitive dulling, and libido issues were starting to get to me. Though first of all I would like to say that for a large segment of those with MDD, that anti depressants will actually increase cognition, once your brain is back to where it was prior to the depression, is when you can start to notice the major dulling. Depression can cause severe psychomotor retardation(decreased cognitive tempo), brain atrophy, hpa dysfunction, and make you slow as molases, with a nasty case of leaden paralysis and apathy. This is all well documented so I won't bother getting into it. I am a firm believer that taking pharmaceutical SSRI's outweighs the risk/damage that will been done if left unmedicated(which happens, usually due to the misinformation).
So with this said, as an experimental person by nature, and being in a position to do so, I decided to see if Zembrin really could match up against a pharmaceutical SSRI. Zembrin is a proprietary extract of Kanna, special in it's production, and alkaloid contents. It has both SSRI, and PDE4 inhibiting properties. Which IMO makes it very specia…
What they were answering
Chargers95 · 2 points
Any word on this? If it reliably delivers more curcumin to the brain than longvida I'd happily make the switch, but as someone with chronic headaches, I'd want the switch to be effective since longvida is already quite effective.
Also, would switching to 400mg x2/day rather than once a day for longvida provide further pain benefits? Something I've heavily been considering
EDIT: or maybe stacking longvida with bioperine?
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
It was only 2 days ago! LOL
I don't think the CuQfen is anything special, TBH. I think he is feeling the effects of the fenugreek. Taking a good fenugreek extract alongside Longvida might give even better effects. We are researching fenugreek now, and figuring out what would be good to standardize to. CurQfen just seems to use the fenugreek galactomannan as the carrier for the curcumin. Interesting idea, but I think a good fenugreek alongside a good curcumin like Longvida might give more flexibility and better effects.