Comment · Tue, October 15, 2019 · Natrium Health & Nootropics Depot
Bacopa Monnieri - Standardised extracts (e.g Synapsa) and HPLC measurements
Original post in this thread
throw_my_username · 9 points
Hello,
I was wondering the following. Most studies on Bacopa use the Synapsa variant and state a dose of ~300mg with 50-55% bacosides.
Now, considering that that bacoside percentage is derived NOT through the accurate HPLC measurement but through UV-spectrophotometry, one can easily demonstrate that e.g Synapsa is, in fact, NOT 50-55% Bacosides but more like ~8% (for an example, see here).
Due to this, if one were to buy a product that claims 50% bacosides by HPLC, would it be reasonable to lower the bacopa recommended dosage by 5 times? So, instead of 300mg used in studies, the HPLC-measured variant would only be 60mg.
A second question I have is this: considering it's the same herb, how is it possible that some people have experienced problems with the non-Synapsa version of Bacopa? What could the Synapsa version have that the "generic" bacopa doesn't that could cause different reactions in the same person?
What they were answering
jarrellt67 · 2 points
Great! Thank you for the update. I'm looking forward to seeing the formula (especially since you mentioned in a previous thread that it doesn't include melatonin).
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Correct. We do offer a side bottle of 300mcg melatonin for people to add on. We just wanted to keep it out of the main formula because a lot of people just can't take it. A side bottle gives people the option to get the best of both worlds.