Comment 路 Tue, October 15, 2019 路 Natrium Health & Nootropics Depot
Bacopa Monnieri - Standardised extracts (e.g Synapsa) and HPLC measurements
Original post in this thread
throw_my_username 路 9 points
Hello,
I was wondering the following. Most studies on Bacopa use the Synapsa variant and state a dose of ~300mg with 50-55% bacosides.
Now, considering that that bacoside percentage is derived NOT through the accurate HPLC measurement but through UV-spectrophotometry, one can easily demonstrate that e.g Synapsa is, in fact, NOT 50-55% Bacosides but more like ~8% (for an example, see here).
Due to this, if one were to buy a product that claims 50% bacosides by HPLC, would it be reasonable to lower the bacopa recommended dosage by 5 times? So, instead of 300mg used in studies, the HPLC-measured variant would only be 60mg.
A second question I have is this: considering it's the same herb, how is it possible that some people have experienced problems with the non-Synapsa version of Bacopa? What could the Synapsa version have that the "generic" bacopa doesn't that could cause different reactions in the same person?
What they were answering
throw_my_username 路 6 points
What can I say? I couldn't ask for a better answer! Thank you.
I wish I could show my support financially. Unfortunately you guys don't have EU warehouses 馃槙. I'd be OK paying shipping if customs wouldn't seize it 馃檮.
Any plans for an European expansion?
Also: considering almost all studies use the "faulty" bacoside measurement and yet they prove to have positive effects, it's safe to assume the herb itself is ok even at very low dosages (~8% for synapsa).
I wonder if the 8 weeks duration for the effects is due to the very small dosage?
EDIT:
I went on your website and couldn't find the Bacopa with ~20% (real) bacosides. Am I blind?
u/MisterYouAreSoDumb 路 Natrium Health & Nootropics Depot
EU warehousing is always something I have wanted, but we have not been able to make the economics of it work yet. We ship to all the countries in the EU, and do daily. There are only a couple where we have issues, and those issues are limited. Where are you in the EU?
Also: considering almost all studies use the "faulty" bacoside measurement and yet they prove to have positive effects, it's safe to assume the herb itself is ok even at very low dosages (~8% for synapsa).
I would not say ALL the studies are on Synapsa. Synapsa is the trademarked name in the US for an extract called CDRI-08. That stands for The Central Drug Research Institute of India. They are a semi-private governmental agency of the government of India. So they do fund a lot of studies. However, Verdure has funded studies on Bacognize as well. 300-320mg is the standard dose for both of them. We are using our 24% (actual UPLC number) extract in our new sleep stack, and we had to lower the dose to 200mg. If you somehow find an actual 50% tested properly (We have yet to do so with a LOT of trying) then I would probably lower the dose again. However, both Bacognize and Synapsa are good around 300mg.
I wonder if the 8 weeks duration for the effects is due to the very small dosage?
Could be. I have not done any acute memory testing with higher doses of our 24% yet. We have mostly been doing sleep studies with it.
I went on your website and couldn't find the Bacopa with ~20% (real) bacosides. Am I blind?
It's not up yet. This has been half a year of lab work and trying to figure all this stuff out with standardizations and testing methodologies. We only recently concluded everything a little bit ago. It should be up very soon, though. I think it might already be done and just waiting to be put on the site.