Comment · Mon, September 9, 2019
Sytrinol for Circadian Rhythm Enhancement
Original post in this thread
ShouldReallyGetWorkn · 7 points
So I was reading through some research and Nobiletin caught my eye as a circadian rhythm enhancement with a connection benefits to aging and metabolic disorders:
​
We previously reported that the small molecule Nobiletin (NOB) activates ROR (retinoid acid receptor-related orphan receptor) nuclear receptors to potentiate circadian oscillation and protect against metabolic dysfunctions. Here we show that NOB significantly improves metabolic fitness in naturally aged mice fed with a regular diet (RD).
https://www.ncbi.nlm.nih.gov/pubmed/31462679
In a second, smaller screen, a natural flavonoid compound called nobiletin (NOB) was identified as a novel CEM, along with its close analog tangeretin
...'
Metabolic characterization illustrated that NOB effectively mitigated body weight gain without altering food intake, stimulated energy expenditure (EE) and circadian activity, enhanced glucose and insulin tolerance, and diminished lipid content in circulation and in liver (74). The alleviated liver steatosis phenotype was accompanied by…
What they were answering
thelonius97 · 1 points
I'm guessing it's a similar story with the majority of the non-nootropic substances you sell? If so, you may want to consider making a sister site/company. But not sure what your niche would be since you don't do mainstream supplements.
u/MisterYouAreSoDumb
No, we have spent the past few years trying to balance our sales across our whole catalog. We were very top heavy for a while, but have slowly balanced things a lot more. That's tough to do, though. When selling things like L-theanine, ashwagandha, rhodiola, etc. we are competing with people that have deeeeep pockets to try and keep their market share. It's dumb sometimes. We've seen them paying $20 per click for a $10 product... Obviously they are not manually bidding on keywords at that size. They have things automated. However, their budgets are just dumb sometimes, and they let the bidding do its own thing. So you get instances where they are paying ridiculous amounts for certain things that make zero sense. They probably don't even know it. It's just a small part of their monthly advertising budget. So we have to be very strategic and diligent in our efforts to find the low hanging fruit we can make ground on. Sometimes you lose a lot of money very quickly on these advertising platforms. It can get crazy.
We have Natrium Health as our other brand doing mainstream supplements. We've spent a LOT of time and money on that. We've been working on Natrium Health for over 3 years now. We are finally in some stores, and are making ground there. Our other operations subsidize Natrium for now, but eventually it will stand on its own. I'm okay losing money for a while, as long as I know where we are headed. We also do a lot of other things in the background that many people here don't know about. We do contract manufacturing, white labeling, and formulation/R&D for a handful of other brands. So we have that revenue stream apart from our retail operations. Then I have built up our analytical testing lab to eventually one day stand on its own as well. So that will be another revenue stream. We are also developing our own patented extracts and novel compounds, which might one day be pretty huge! As a company we are very well balanced right now. I saw the writing on the wall years ago. So I have been diversifying us for a long time. We are faaaaar from where I want us, but also far from where we came.