Comment · Fri, September 6, 2019
Sytrinol for Circadian Rhythm Enhancement
Original post in this thread
ShouldReallyGetWorkn · 7 points
So I was reading through some research and Nobiletin caught my eye as a circadian rhythm enhancement with a connection benefits to aging and metabolic disorders:
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We previously reported that the small molecule Nobiletin (NOB) activates ROR (retinoid acid receptor-related orphan receptor) nuclear receptors to potentiate circadian oscillation and protect against metabolic dysfunctions. Here we show that NOB significantly improves metabolic fitness in naturally aged mice fed with a regular diet (RD).
https://www.ncbi.nlm.nih.gov/pubmed/31462679
In a second, smaller screen, a natural flavonoid compound called nobiletin (NOB) was identified as a novel CEM, along with its close analog tangeretin
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Metabolic characterization illustrated that NOB effectively mitigated body weight gain without altering food intake, stimulated energy expenditure (EE) and circadian activity, enhanced glucose and insulin tolerance, and diminished lipid content in circulation and in liver (74). The alleviated liver steatosis phenotype was accompanied by…
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Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
Sytrinol is literally a really cool product! However, NOBODY buys it. So we are likely going to drop it. It has so many cool novel effects, though. So it sucks. We could try and convince people how cool it is, but our efforts in the past have not led to much. I can count the number of people who buy it monthly on one hand.