Comment · Tue, October 1, 2019
Sytrinol for Circadian Rhythm Enhancement
Original post in this thread
ShouldReallyGetWorkn · 7 points
So I was reading through some research and Nobiletin caught my eye as a circadian rhythm enhancement with a connection benefits to aging and metabolic disorders:
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We previously reported that the small molecule Nobiletin (NOB) activates ROR (retinoid acid receptor-related orphan receptor) nuclear receptors to potentiate circadian oscillation and protect against metabolic dysfunctions. Here we show that NOB significantly improves metabolic fitness in naturally aged mice fed with a regular diet (RD).
https://www.ncbi.nlm.nih.gov/pubmed/31462679
In a second, smaller screen, a natural flavonoid compound called nobiletin (NOB) was identified as a novel CEM, along with its close analog tangeretin
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Metabolic characterization illustrated that NOB effectively mitigated body weight gain without altering food intake, stimulated energy expenditure (EE) and circadian activity, enhanced glucose and insulin tolerance, and diminished lipid content in circulation and in liver (74). The alleviated liver steatosis phenotype was accompanied by…
What they were answering
AJolly · 1 points
I mean, this is the first I'm even hearing about it, and I don't see any other posts about it on Reddit.
I did find a link to someone saying it's helped with autism, but only for a few days. (Worth reading this blog btw) https://epiphanyasd.blogspot.com/2018/10/ketones-and-autism-part-6-capric-acid.html
u/MisterYouAreSoDumb
Nobody has really talked about it on Reddit. We sent a few subscriber emails on it a while back, but didn't get much out of it.