Comment · Wed, July 17, 2019 · Natrium Health & Nootropics Depot
What they were answering
Chargers95 · 1 points
Question for your lab director if possible. Does Urolithin A cross the BBB?
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Yes
Computational studies found that polyphenols could not cross the blood-brain barrier, but that urolithins could.
Comment · Mon, June 17, 2019 · 21 pts
Urolithin A is a metabolite of the punicalagins in Pomella. There are even studies on Pomella and this compound. We mention Urolithin A on our product page as well. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359844/
Comment · Mon, June 17, 2019 · 17 pts
The punicalagins that lead to increased levels of Urolithin A are highest in the husk of the pomegranate. So you would need to eat that nasty husk to get them. An extract is much more feasible.
Comment · Tue, June 18, 2019 · 6 pts
I don't offhand. I am speaking with my lab manager now about using the AOAC punicalagin testing method to estimate how much urolithin A you might get. It is going to depend on your gut microflora, though. So it is not an
Comment · Tue, June 18, 2019 · 6 pts
He is talking about the bioavailability of exogenously supplemented ellagic acid, not its ability to be converted in-vitro in a controlled study. Its bioavailability has been questioned in the past, but those studies may
Comment · Tue, June 18, 2019 · 3 pts
The husk is the whole outside of it. You could blend the whole pomegranate and consume it all. It will just be bitter.
Comment · Fri, June 21, 2019 · 2 pts
I never suggested it did. The person you were responding to may have been trying to make that point. However, I was just linking to a study that was discussing the limitations of supplementing free EA, because I had also
Comment · Fri, June 21, 2019 · 1 pts
It's possible. It would be a multi-step process of hydrolysis, dehydroxylation, and decarboxylation. This process happens in your GI tract due to bacteria, which is why there is variability in how much is created in some
Comment · Thu, July 4, 2019 · 1 pts
Possible, if we can make the numbers work.
Comment · Thu, July 4, 2019 · 1 pts
Any brand new product like this would realistically be at least 2-3 months off at minimum. There's a lot of leg work we need to do these days to bring new things out.
Comment · Tue, July 16, 2019 · 1 pts
It's not a direct relationship, as it depends on your probiotics to convert it. So we can't really say X amount of Pomella will lead to Y amount of urolithin A. We are working on a direct supplement for urolithin A, thou
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